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Carvedilol arrestin

Carvedilol arrestin

The b-AR GRK/b-arrestin biased agonist carvedilol can induce b-AR–mediated transactivation of the EGFR. The initial purpose of this study. Additionally, one compound, carvedilol, possessed unique signaling profile of Intriguingly, carvedilol stimulated phosphorylation of the b2AR, b-arrestin.

Carvedilol arrestin

Official Full-Text Paper (PDF): Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Wisler JW(1), DeWire SM, Whalen EJ, Violin JD.

Carvedilol arrestin

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