Baclofen is a useful drug for this pathology and is usually administered orally; however, due to its low bioavailability or poor tolerance some patients require.
Efficacy of intrathecal morphine in the treatment of baclofen tolerance in a patient on intrathecal baclofen therapy (ITB). J Vidal, P Gregori, D Guevara, E Portell. Intrathecal Fentanyl Alleviates Spasticity in the Presence of Tolerance to Intrathecal Baclofen. CHARLES CHABAL, M.D.; LOUIS JACOBSON, M.D.; GREGORY. Continuous Intrathecal Baclofen (ITB) Infusion for severe spasticity and dystonia such as physical tolerance, psychological dependency, and neurotoxicity.
Intrathecal baclofen (ITB) administration via a programmable implanted Due to tolerance, the dose of ITB needs to be gradually increased over a period of six.