Sildenafil biochemistry

In addition, it has been reported that sildenafil, a well-known PDE-5 inhibitor, can directly relax human bladder strips and that this effect involves the H2S. Treatment options for erectile impotence include oral therapy in the form of PDE-5 inhibitors (sildenafil, vardenafil, and tadalafil), intraurethral alprostadil.

Viagra. In a random survey of males aged 40-70, more than 50 percent indicated that they had some form of erectile dysfunction (ED), i.e., the inability to achieve. Sildenafil works by inhibiting the enzyme PDE5 by occupying its active site show different behaviour when subjected to physical biochemical techniques.

The erectile dysfunction medicine sildenafil citrate (Viagra®) inhibits of some biochemical process, such as the hydrolysis of cGMP catalyzed by PDE6*).